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| SWI (a) and GRE (b) MRI images of a stroke case (2). |
Continuing the topic of cerebral microbleeds from last week, a recent study by Yan and colleagues investigates the clinical relevance of the presence of CMBs in ischemic stroke patients when undergoing thrombolytic treatments:
Extensive cerebral microbleeds predict parenchymal haemorrhage and poor outcome after intravenous thrombolysis. Yan S, Jin X, et al. J Neurol Neurosurg Psychiatry. 201
The purpose of this study was to evaluate the impact of CMB
on clinical outcomes of ischemic stroke patients after thrombolytic treatments.
Susceptibility weighted imaging was exclusively used to image patients before
and after treatment with recombinant tissue plasminogen activator (rtPA). Two
investigators blinded to 333 patients’ clinical data jointly reviewed the MRI
findings for CMBs by frequency and location using detection criteria described
by Greenberg et al. Analysis was done on the hemorrhagic transformation
subtypes: hemorrhagic infarction (HI), and parenchymal hemorrhage (PH),
extra-ischemic hemorrhage, and symptomatic intracranial hemorrhage (sICH).
NIHSS scores independently predicted hemorrhagic transformation for HI, and PH.
On SWI, 742 CMBs were detected in 133 patients.
The
presence of ≥ 3 CMBs independently predicted parenchymal hemorrhage and poor
clinical outcome after intravenous thrombolysis.
MR Innovations is on the cutting edge of detection, location, and quantification of cerebral microbleeds. For more information on SWI and MRI post-processing and analysis, please visit www.mrinnovations.com.
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